Flashing Light, Sound Restore Memory in Alzheimer’s Mice

An innovative light and sound stimulation therapy reduced the number of amyloid plaques found in the brains of laboratory mice with Alzheimer’s disease, improving memory and cognitive function. The disease is caused by the buildup of two proteins in the brain—amyloid beta and tau—that clump together to form plaques or neurofibrillary tangles that impair memory function. In 2016, Li-Huei Tsai, director of MIT’s Picower Institute for Learning and Memory, and her team exposed laboratory mice that genetically predisposed to Alzheimer’s disease to a light flickering at 40 hertz for one hour a day.

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