At Atomwise, we invented the first deep learning neural networks for structure-based small molecule drug discovery and we’re currently deploying it in one of the largest applications of machine learning for life sciences. You should think about joining us if you care about enabling the application of machine learning to important problems. That team headcount includes the manager who has a technical background and, at the time of this writing, still contributes code.

Recent investigations by InsideClimate and The Union of Concerned Scientists unearthed internal company documents from 1982, revealing that Exxon’s research team was performing groundbreaking climate research and very clearly understood the consequences of carbon emissions from fossil fuels on the planet. In 1978 senior scientist James Black gave a company talk where he described the “general scientific agreement” that human-produced CO2 emissions from fossil fuels were influencing the climate. Exxon doubled down on their research, and in the early 80s published several papers on climate change in scientific journals, gaining a reputation of “genuine expertise” on the subject.

That was how one MTA New York City Transit source with knowledge of the situation described the latest curiosity to befall the city’s beleaguered subway. Eleven minutes later, a New York City Transit employee on duty at 14th St-Union Square (one express stop uptown from Brooklyn Bridge) spotted another “surfer” on the back of an uptown 6 local train as it left the station. Every New York City Transit employee gave the same description of the “surfer” they saw riding the back of the train or darting across the tracks: young, male, wearing black clothing and white sneakers.

According to the plan, the currently car-filled bridge connecting the Eiffel Tower with the Métro subway system will be turned into a pedestrianized garden, stringing together a set of two new public squares and restored parkland that will create an unbroken spine of greenery a mile long across the city. The plan would slash car traffic in the immediate vicinity of the Eiffel Tower, making the area altogether more inviting to walkers without notably altering the appearance of what could be the most famous urban ensemble in the world. Tunneling for traffic on the right bank will create another pedestrian square, called Place Branly, while a riverside garden promenade will continue up river to the elevated Bir Hakeim Métro station, the other main access point for the tower.

Here is an example of a Terraform configuration showing some new language features:

We have many resources available for 0.12 for new and existing users. Prior versions of Terraform reduced plan output to a flat list of key, value pairs, even when using resource types with deeply-nested configuration blocks. Terraform 0.12 has an entirely new plan renderer which integrates with Terraform’s new type system to show changes in a form that resembles the configuration language, and which indicates nested structures by indentation:

Along with reflecting the natural configuration hierarchy in the plan output, Terraform will also show line-oriented diffs for multiline strings and will parse and show structural diffs for JSON strings, both of which have been big pain points for plan readability in prior versions.

The famous 1981 Byte magazine issue that popularized Smalltalk and OOP explicitly says “the fundamental idea of objects, messages, and classes came from SIMULA.” More recently people keep claiming that OOP “isn’t really” about classes and objects and the important bit is actually the messages. In the Smalltalk-72 manual he says (p. 18)

Looking at the early sources, everybody acts as if OOP consisted of three major ideas: classes that defined protocol and implementation, objects as instances of classes, and messages as the means of communication.

The molybdenum isotopes allow us to clearly distinguish carbonaceous and non-carbonaceous material, and as such represent a ‘genetic fingerprint’ of material from the outer and inner solar system,” explains Dr. Gerrit Budde of the Institute of Planetology in Münster and lead author of the study. The measurements made by the researchers from Münster show that the molybdenum isotopic composition of the Earth lies between those of the carbonaceous and non-carbonaceous meteorites, demonstrating that some of Earth’s molybdenum originated in the outer solar system. Budde et al, Molybdenum isotopic evidence for the late accretion of outer Solar System material to Earth,
Nature Astronomy (2019).

Serenity is a love letter to ’90s user interfaces, with a custom Unix-like core. Go into the Toolchain/ directory and run the BuildIt.sh script. Otherwise, see the older step-by-step guide to building Serenity

Come chat in on the Freenode IRC network.

It’s twelve brand new video games, one each week. When your Playdate lights up with a brand new game delivery, we hope you can’t wait to unwrap your gift. Playdate is alive with possibilities and surprises, future games and new ways to make them.

KASHGAR, China — A God’s-eye view of Kashgar, an ancient city in western China, flashed onto a wall-size screen, with colorful icons marking police stations, checkpoints and the locations of recent security incidents. The simulation, presented at an industry fair in China, offered a rare look at a system that now peers into nearly every corner of Xinjiang, the troubled region where Kashgar is located. This is the vision of high-tech surveillance — precise, all-seeing, infallible — that China’s leaders are investing billions of dollars in every year, making Xinjiang an incubator for increasingly intrusive policing systems that could spread across the country and beyond.