A DNA-based voltmeter for organelles

We describe a DNA-based fluorescent reporter that quantitates membrane potential and can be targeted to specific organelles in live cells. We could thereby measure the membrane potential of different intracellular organelles in living cells, which has not been possible previously. Our understanding of how membrane potential regulates organelle biology is poised to expand through the use of these new sensors.

Source: www.biorxiv.org