P. gingivalis in Alzheimer’s disease brains

Doses of 10 and 30 mg/kg reduced P. gingivalis load, Aβ 1–42 , and tumor necrosis factor–α (TNFα) levels in brain tissue compared to those of infected animals treated with vehicle ( Fig. 8, J to L ). On the basis of the superior performance of the highly potent and specific Kgp inhibitor COR271 in the above in vivo mouse study in clearing P. gingivalis brain infection and protecting Gad67 + neurons in the hippocampus compared to an Rgp inhibitor and a broad-spectrum antibiotic, we developed the COR271 analog COR388. ( A ) P. gingivalis PCR product in mouse brains after oral infection with P. gingivalis W83, with or without treatment with the Kgp inhibitor COR119, or infection with gingipain knockout strain ΔRgpB or ΔKgp.

Source: advances.sciencemag.org