Mechanism of hardening of the arteries and potential treatment identified

Mechanism of hardening of the arteries and potential treatment identified

The team, led by the University of Cambridge and King’s College London, found that a molecule once thought only to exist inside cells for the purpose of repairing DNA is also responsible for hardening of the arteries, which is associated with dementia, heart disease, high blood pressure and stroke. Supported by funding from the British Heart Foundation, the researchers found that poly(ADP ribose), or PAR, a molecule normally associated with DNA repair, also drives the bone-like calcification of arteries. Having discovered the links between DNA damage, PAR, bone and artery calcification, the researchers then looked into a way of blocking this pathway through the use of a PARP inhibitor.

Source: www.cam.ac.uk

GitHub Hires Former Bitnami Co-Founder Erica Brescia as COO

GitHub Hires Former Bitnami Co-Founder Erica Brescia as COO

It’s been just over a year since Microsoft bought GitHub for $7.5 billion, but the company has grown in that time, and today it announced that it has hired former Bitnami COO and co-founder Erica Brescia to be its COO. She sees that experience of building a company, of digging in and taking on whatever roles the situation required, translating well as she takes over as COO at a company that is growing as quickly as GitHub. “I was really shocked to see how quickly GitHub is still growing, and I think bringing that kind of founder mentality, understanding where the challenges are and working with a team to come up with solutions, is something that’s going to translate really well and help the company to successfully scale,” Brescia told TechCrunch.

Source: techcrunch.com

C64 Power C Tutorial

C64 Power C Tutorial

As you can see, cc65 produces slightly faster code, while the code produced by Power C is a little smaller. In my opinion, compiling C to correct, fast, and efficient machine language is the primary purpose of a C compiler, and that’s why I consider Power C to be the superior package. These days, D64 images of both disk sides, as well as many other useful libraries and utilities for Power C can be downloaded from Glenn Holmer’s website.

Source: 64k.blot.im

Performance Speed Limits

Performance Speed Limits

You can do that by:

Intel, AMD: One operation per port, per cycle

Let us use our newfound knowledge of the pipeline width limitation, and tackle another example loop:

The loop compiles to the following assembly. You can get this information from Agner’s instruction tables:

On modern Intel some simple integer arithmetic ( , , , ), bitwise ( , , ) and test ( , ) run on four ports, so you aren’t very likely to see a port bottleneck for these operations (since the pipeline width bottleneck is more general and is also four), but many operations complete for only a few ports. Modern Intel and AMD chips (and many others) have a limit of two loads per cycle, which you can achieve if both loads hit in L1.

Source: travisdowns.github.io

Hacking My Mother’s Phone to Save Her Memories

Hacking My Mother’s Phone to Save Her Memories

And then there is the inadvertent record: the enraged first drafts, the unflattering selfies, the record of purchases at Amazon or Netflix, the digital sticky notes we had not meant to keep. If the only way to preserve her memories was to put together the pieces of her digital life, then we had to hack into her online accounts. I patted myself on the back for having insisted Mom record her passwords, and we sisters rejoiced … for about five minutes.

Source: www.nytimes.com

RAMBleed Attack – Reading Bits in Memory Without Accessing Them

RAMBleed Attack – Reading Bits in Memory Without Accessing Them

RAMBleed is based on a previous side channel called Rowhammer, which enables an attacker to flip bits in the memory space of other processes. Furthermore, unlike Rowhammer, RAMBleed does not require persistent bit flips, and is thus effective against ECC memory commonly used by server computers. The attacker can then use Rowhammer to induce bit flips in her own memory, thereby leaking the victim’s secret data.

Source: rambleed.com

The War to Free Science

The War to Free Science

That’s because in February, the UC system — one of the country’s largest academic institutions, encompassing Berkeley, Los Angeles, Davis, and several other campuses — dropped its nearly $11 million annual subscription to Elsevier, the world’s largest publisher of academic journals. Elsevier owns around 3,000 academic journals, and its articles account for some 18 percent of all the world’s research output. How academic journals became so unaffordable

Scientific journals, published mainly by small scientific societies, sprouted up alongside the printing industry in the 17th century as a way to disseminate science and information about scientific meetings.

Source: www.vox.com

Canada Plans to Ban Single-Use Plastics, Joining Growing Global Movement

Canada Plans to Ban Single-Use Plastics, Joining Growing Global Movement

Mr. Trudeau noted that Canada threw away 8 billion Canadian dollars’ worth of plastic material each year. According to Environment and Climate Change Canada, the national environmental agency, that includes more than 34 million plastic bags each day. But Mr. Trudeau said Canada expected to follow the example of the European Union, which voted in March to ban 10 single-use plastics that most often end up in the ocean, including plastic cutlery, plates and cotton-swab sticks.

Source: www.nytimes.com

Cause of hardening of the arteries and potential treatment identified

Cause of hardening of the arteries and potential treatment identified

The team, led by the University of Cambridge and King’s College London, found that a molecule once thought only to exist inside cells for the purpose of repairing DNA is also responsible for hardening of the arteries, which is associated with dementia, heart disease, high blood pressure and stroke. Supported by funding from the British Heart Foundation, the researchers found that poly(ADP ribose), or PAR, a molecule normally associated with DNA repair, also drives the bone-like calcification of arteries. Having discovered the links between DNA damage, PAR, bone and artery calcification, the researchers then looked into a way of blocking this pathway through the use of a PARP inhibitor.

Source: www.cam.ac.uk

Support for U2F security keys

Support for U2F security keys

You can now use U2F-compatible security keys as a second factor for your 1Password account. You can add your security keys now by heading over to the 1Password web app and visiting our new Two-Factor Authentication page. Offer expires June 12, 2019 at 8 a.m. PST.Get your YubiKey

How it works under the hood
WebAuthn is a pretty neat implementation based on public key crypto, and resolves security vulnerabilities like phishing.

Source: blog.1password.com